The Role of VDR in the Intestinal Microbiome

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Each of our data suggest that active one particular, 25D signaling enriched Aire+ mTECs and enhanced their very own colocalization with the transcribing factor Vdr. The incomplete overlap amongst the binding sites of the two proteins is consistent with the pleiotropic actions of both molecules and shows that they may socialize functionally. one particular, 25D improved the expression of Aire mRNA and improved the number of Aire+ cells in thymic pieces, and induced Aire-dependent TRA mRNAs in sorted TEC populations. 1, 25D treatment also improved Vdr colocalization with Castillo in mTECs, cTECs, and thymocytes.

We showed that digestive tract epithelial VDR regulates autophagy through the interaction while using protein ATG16L1 and that decreased intestinal VDR expression correlates with dysbiosis in a colitis model. Maintenance of the bacterial product butyrate increases intestinal epithelial VDR expression and restores microbial homeostasis. This can be the first demo that VDR impacts the intestinal tract microbiome through its communication with ATG16L1 and autophagy. We suggest that intestinal epithelial ideals VDR VDR is a main regulator of intestinal homeostasis and that modulation of this receptor could be an powerful therapeutic technique to treat inflammatory bowel disease.